Model-Based Recursive Partitioning for Subgroup Analyses
نویسندگان
چکیده
منابع مشابه
Subgroup Analysis via Recursive Partitioning
Subgroup analysis is an integral part of comparative analysis where assessing the treatment effect on a response is of central interest. Its goal is to determine the heterogeneity of the treatment effect across subpopulations. In this paper, we adapt the idea of recursive partitioning and introduce an interaction tree (IT) procedure to conduct subgroup analysis. The IT procedure automatically f...
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Identification of subgroups of patients for which treatment A is more effective than treatment B, and vice versa, is of key importance to the development of personalized medicine. Several tree-based algorithms have been developed for the detection of such treatment-subgroup interactions. In many instances, however, datasets may have a clustered structure, where observations are clustered within...
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The party package (Hothorn, Hornik, and Zeileis 2006) provides the function mob() implementing a recently suggested algorithm for model-based recursive partitioning (Zeileis, Hothorn, and Hornik 2005). The basic steps are: (1) fit a parametric model to a data set, (2) test for parameter instability over a set of partitioning variables, (3) if there is some overall parameter instability, split t...
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ژورنال
عنوان ژورنال: The International Journal of Biostatistics
سال: 2016
ISSN: 2194-573X,1557-4679
DOI: 10.1515/ijb-2015-0032